About Lexeo 

Lexeo Therapeutics is a New York City-based, clinical-stage genetic medicine company dedicated to transforming healthcare by applying pioneering science to fundamentally change how genetically defined cardiovascular diseases and APOE4-associated Alzheimer’s disease are treated. Using a stepwise development approach, Lexeo is leveraging early proof-of-concept functional and biomarker data to advance a pipeline of cardiovascular and APOE4-associated Alzheimer’s disease programs. 

Primary Responsibilities 

• Lead and contribute to the design, execution, and interpretation of experiments to validate novel drug targets. 
• Oversee design and screening of new AAV constructs for discovery  
• Develop and optimize assays and screening strategies to characterize lead gene therapy candidates.  
• Collaborate with cross-functional teams to advance drug discovery and development projects. 
• Analyze and interpret data from in vitro and in vivo pharmacology &safety studies. 
• Research latest scientific trends and technological advances in gene therapy. 
• Design and oversee preclinical studies to evaluate the efficacy and safety of candidate therapeutics. 
• Contribute to the preparation of regulatory documents, including IND submissions. 
• Mentor and supervise junior scientists in a cross-functional setting. 
• Present research findings at internal meetings, scientific conferences, and in peer-reviewed publications. 

  Required Skills & Qualifications 

• Ph.D. in Molecular Biology, Genetics, Bioengineering, or a related field. 
• 5+ years of post-Ph.D. experience in a biotech/pharma setting, with a focus on gene therapy research.  
• Drug Discovery for gene therapy or nucleic acid medicines  
• Familiar with AAV gene therapy design and development   
• CRO management for conducting in vivo research studies  
• Designing in vivo gene therapy studies and dosing  
• Experience in biodistribution studies and pharmacology related to gene therapy applications.  
• Gene therapy assay development   
• Designing IND-enabling studies is a plus.  
• Deep understanding of molecular biology techniques (RNA/DNA isolation, ddPCR, RNAscope, western blot)  
• AAV vector design, titering, dosing  
• Expertise in in vivo models for biodistribution and pharmacology studies.  
• Strong analytical skills and proficiency in statistical data analysis.  
• Excellent communication and project management abilities.  
• Graphpad, excel etc.   

Anticipated Salary Range
Depending on qualifications and overall experience, base salary is likely to $150,000 - $190,000 per year. 

Lexeo Therapeutics is an EEO employer committed to an exciting, diverse, and enriching work environment.